The hand-foot syndrome in sickle-cell haemoglobinopathy.

Can Trimodal Distribution of HbS Levels in Sickle Cell Traits Be Used To Predict the Associated Alpha-Thalassemia For Screening Cases in Central India?

Background: Until now, trimodal distribution of HbS has been seen by six different studies in the world when associated with alpha-thalassemia with confirmation by corresponding alpha-genotyping studies. The RBC indices reduce as alpha-globin genes reduce in sickle cell trait (SCT) patients, which decreases the extent of intra-vascular sickling and thus betters the clinical cou...

Salmonella osteomyelitis presenting as "hand-foot syndrome" in sickle-cell disease.

Autologous immune complex nephritis associated with sickle cell trait: diagnosis of the haemoglobinopathy after renal structural and immunological studies.

A renal tubular epithelial antigen (RTE)--anti-RTE autologous immune complex nephritis associated with sickle cell anaemia (SS) has been reported, but immune complex nephritis has never been described in patients with sickle cell trait (SA). During investigation of a child with "asymptomatic proteinuria" cryoprecipitable complexes of RTE-anti-RTE were detected in the serum and granular deposits...

Hip arthroplasty in patients with sickle-cell haemoglobinopathy.

We reviewed retrospectively 25 hip arthroplasties in 25 patients with sickle-cell haemoglobinopathy and osteonecrosis. The mean age of the ten women and 15 men at the onset of hip symptoms was 25 years, and at surgery 30 years (16 to 45); 66% had either SS or S-thal disease, 20% sickle-cell trait, and the remainder SC disease. The mean follow-up was 8.6 years (two to 18). Fourteen (40%) of the ...

Sickle cell disease and related hemoglobinopathies.

Objectives 1. Describe different combinations of normal and abnormal hemoglobins and their phenotypic expression 2. Describe the pathophysiology of vasooclusion secondary to hemoglobinopathies 3. Define and describe hand-foot syndrome 4. Describe features of osteomyelitis secondary to sickle cell disease and its differentiation from bone infarct 5. Describe features of avascular necrosis of bon...